Technology Overview

Sustained Release

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Oral dosage form;
Hydrophilic-Hydrophobic matrix approach;
Incorporation of up to 600 mg of API on 1500 mg embossed tablet possible;
Duration of release up to 24 hours;

Effervescent products are based on a chemical incompatibility between bicarbonate and an acidic source.
This reaction is an autocatalytic reaction catalysed by the presence of water and heat, that generates CO2 in solution.
The control of the reaction is made by a strict control of the residual amount of moisture during the process and on the final dosage form (tablets).

ODT – Fast Melt Technology Overview

Advanced patented technology based on:

  • wet granulation of drug and excipients in a fluid bed granulator;
  • moisture control during the process and in the manufacturing area;
  • tabletting and packaging.

Simple, inexpensive formulation and manufacturing process and tablets robust enough to be shipped overseas in bulk for final packaging to be completed in the US.

High drug loading: from a few micrograms up to 400-500 mg per tablet.

Effective taste masking and wide application.
Ability to incorporate modified release components: allow for controlled release of the drug according to a desired PK profile.

Patent Protection: The fast melt patent issued in the US in 2000, and is pending in other countries

Granular Technology Overview

Granular comes in sachets in either Effervescent or Non Effervescent form.

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Technologies of Alpex Pharma