| 1988 | The company started in 1988 under the name Aesculapius Pharma. |
| 1992 | In 1992 Aesculapius Pharma was acquired by Elan Corporation PLC and since the acquisition heavy investement have been made in R&D (fast melt technology) and manufacturing facility. |
| 1998 | The first fast melt nutritional product was commercialised in 1998. |
| 2001 | The first fast melt pharmaceutical product was commercialised in 2001. |
| 2004 | In 2004, the majority of capital shares of the company was aquired by funds managed by Sanders Morris Harris, USA, and changed the name to Alpex Pharma |
| 2007 | Capital increase and entrance of BB Biotech fund in the Alpex’s capital. |